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National Repository of Grey Literature 3 records found  Search took 0.00 seconds. 
Preparation of enantiomerically pure lactams based on the organocatalysis
 Humpl, Marek ; Veselý, Jan (advisor) ; Jindřich, Jindřich (referee)
Different catalytic approaches have been applied to new -lactams preparations. olefin metathesis has been successfully performed with 3--methylidene--lactams. It was verified that 3--methylidene--lactams olefin metathesis is applicable to preparation of biologically active -lactam of Ezetimibe-type.
Detailed record
Preparation of biologically active compounds using organocatalysis
 Šimek, Michal ; Veselý, Jan (advisor) ; Kočovský, Pavel (referee)
This diploma thesis deals with the use of organocatalysis in an asymmetric allylic substitution reaction of Morita-Baylis-Hillman carbonates by aniline derivatives leading to enantiomerically enriched allylic amines. The first part of the thesis is focused on optimizing the reaction conditions in the organocatalytic reaction with respect to the yields and enantiomeric excesses of the products. In the second part of the thesis prepared enantiomerically enriched allylic amines are used in the cyclization step to give β-lactame cycles that serve as the key intermediates in the total synthesis of Ezetimib as is demonstrated in the final part of the diploma thesis.
Detailed record
Preparation of enantiomerically pure lactams based on the organocatalysis
 Humpl, Marek ; Veselý, Jan (advisor) ; Jindřich, Jindřich (referee)
Different catalytic approaches have been applied to new -lactams preparations. olefin metathesis has been successfully performed with 3--methylidene--lactams. It was verified that 3--methylidene--lactams olefin metathesis is applicable to preparation of biologically active -lactam of Ezetimibe-type.
Detailed record

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